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A 15-year-old boy from the Pontypool area was pronounced dead at the scene by paramedics from the Welsh Ambulance Service.
A 14-year-old girl from the Blaenavon area sustained critical injuries and was taken to the University Hospital of Wales for treatment by the Welsh Air Ambulance.
The boy’s next of kin have been made aware and are being supported by specialist officers.
Anyone with information which could assist the investigation is asked to call 101, quoting log reference 2200225719 or send us a direct message on Facebook or Twitter.
Alternatively, you can contact Crimestoppers anonymously on 0800 555 111.