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Officers attended, along with paramedics from the Welsh Ambulance Service. The collision involved a car and a jeep.
A 29-year-old woman from Cwmbran was taken to the Grange University Hospital and a 23-year-old-woman from Newport to the University Hospital Wales for treatment.
The driver of the car, a black Seat Ateca, reportedly left the scene following the collision and enquiries are ongoing to identify this person. He is believed to be a man in his thirties
Officers are concerned for his welfare and urge him to get in touch with us.
Anyone with details can call 101 or send us a direct message on social media, quoting log reference 2200380061.
You can also call contact Crimestoppers anonymously with information by calling 0800 555 111.