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The neighbourhood policing team raided a property on an industrial estate in Llanhilleth at around 12.30pm, before carrying out a thorough search of the premises.
They found a large commercial operation within, containing hundreds of plants and drug paraphernalia.
A further search resulted in officers finding and arresting two people on suspicion of drug offences.
Two men, aged 29 and 40, were subsequently charged with producing a controlled drug of class B and were due to appear at Newport Magistrates Court on Monday 4 November.