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We’re appealing for information after a road traffic collision on Castle Street, near Castle Court Shopping Centre, Caerphilly, at around 3pm on Tuesday 19 November.
Officers attended, alongside the Welsh Ambulance Service and Wales Air Ambulance.
The collision involved a van and two pedestrians.
A 71-year-old man and a 14-year-old girl were taken to hospital for treatment; they are both in a critical condition.
A 24-year-old man from the Cardiff area was arrested on suspicion of causing serious injury by dangerous driving, and driving whilst over the prescribed limit of drugs.
He remains in police custody at this time.
Sergeant Lewys Davies, the senior investigating officer said: "We’re carrying out a thorough investigation into this collision and ask that members of the community do not speculate about the circumstances on social media as this might hinder our enquiries.
“You will see an increased police activity in this area over the coming days while our investigation continues. Please stop and talk to us if you have any concerns or relevant information.”
Motorists with dashcam footage who were travelling on Castle Street in Caerphilly between 2.45pm and 3pm on Tuesday 19 November, can contact us via the website, call 101 or send us a direct message on social media, quoting log reference 2400385445.
Alternatively, you can call Crimestoppers, anonymously, on 0800 555 111 with information.